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7 Copper-tripeptide complexes stimulate dermal papilla cell proliferation and shift these cells toward survival by raising the Bcl-2/Bax ratio and reducing apoptosis markers

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Kyle KA, Willett TL, Baggio LL, Drucker DJ, Grynpas MD

Interestingly, while oxyntomodulin-bound GLP-1R displayed a more similar TMD conformation to that bound to GLP-1 in the static cryo-EM structure, the effect of mutagenesis was more divergent, with numerous mutations differentially impacting oxyntomodulin affinity and/or signalling data relative to GLP-1 (Fig